Substance use and addiction are centuries-old epidemics. Overdoses have taken the lives of millions, more now with the appearance of COVID19 increasing around the world. Little attention is given to the causation of this wave of substance use with its addiction that crashed against the human species. Relapses seem to be the norm. For the first time, substance use disorder and addiction have a holistic approach with human engineering, proving understanding and outcomes that move addicts to a new dimension in living life, substance-free, and responsible.